S. 1006Senate117th Congress (2021-2023)In Committee

Stopping Overdoses of Fentanyl Analogues Act

Introduced March 25, 2021

AI-Generated Summary

Updated February 8, 2026 at 1:02 AM UTC

The Stopping Overdoses of Fentanyl Analogues Act amends the Controlled Substances Act to place a range of fentanyl‑related chemicals into Schedule I, the category for substances with no accepted medical use. It creates a broad definition of “fentanyl‑related substances” that covers any compound, mixture, or preparation containing these chemicals, their salts, isomers, or similar structures. The law would affect manufacturers, distributors, prescribers, and anyone possessing or trafficking these substances. It takes effect one day after enactment.

Key Provisions

  • Adds specific fentanyl analogues (Isobutyryl fentanyl, Para‑Methoxybutyrylfentanyl, Valeryl fentanyl, Cyclopentyl fentanyl, Para‑Chloroisobutyryl fentanyl) to Schedule I.
  • Expands Schedule I to include any material containing fentanyl‑related substances, their salts, isomers, or salts of isomers, unless specifically exempted.
  • Defines “fentanyl‑related substances” based on structural modifications such as changes to the phenyl portion, phenethyl group, piperidine ring, aniline ring, or N‑propionyl group, and lists additional named analogues (e.g., 4′‑Methyl acetyl fentanyl, Crotonyl fentanyl, etc.).
  • Specifies that the amendments become effective one day after the Act is enacted.

Legislative Activity

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1 earlier action
SenateIntro Referral Latest Action

Read twice and referred to the Committee on the Judiciary.

March 25, 2021

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SenateIntro Referral

Introduced in Senate

March 25, 2021

SenateIntro Referral

Read twice and referred to the Committee on the Judiciary.

March 25, 2021

Floor Debate

5 members

What members said about S. 1006 on the floor

3 Republicans2 Democrats
Rob Portman
Sen. Rob PortmanR-OH · Sep 28, 2022

Madam President, before I rise to talk about Ukraine tonight, I want to join my colleagues in extending my prayers to all those who are currently in Florida, in the area, and those with loved ones…

Ron Johnson
Sen. Ron JohnsonR-WI · Sep 28, 2022

Mr. President, I rise today to tell a story of one family's tragedy but also of two wonderful people who turned that tragedy into helping others and finding solutions. On May 15, 2014, a 19-year-old…

Richard J. Durbin
Sen. Richard J. DurbinD-IL · Sep 28, 2022

Reserving the right to object. Mr. President, I took chemistry in high school. I wasn't very good at it, but I think I got a B, and I was glad to get rid of it because I didn't understand a lot of…

Chuck Grassley
Sen. Chuck GrassleyR-IA · Sep 28, 2022

Mr. President, I ask unanimous consent that the order for the quorum call be rescinded. Mr. President, home should be the safest place in the world for a child. It used to be that parents could…

Jon Ossoff
Sen. Jon OssoffD-GA · Sep 28, 2022

Mr. President, I rise this afternoon in pursuit of justice for the Black men and Black women abducted, beaten, and killed during the segregation era in the American South and in retaliation for their…

Bill Text

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Introduced in SenateIssued March 25, 2021

II

117th CONGRESS

1st Session

S. 1006

IN THE SENATE OF THE UNITED STATES

March 25, 2021

Mr. Johnson (for himself, Mrs. Blackburn, Mr. Braun, Mr. Cassidy, Mr. Cotton, Ms. Ernst, Mr. Lankford, and Mr. McConnell) introduced the following bill; which was read twice and referred to the Committee on the Judiciary

A BILL

To amend the Controlled Substances Act to list fentanyl-related substances as schedule I controlled substances.

1.

Short title

This Act may be cited as the Stopping Overdoses of Fentanyl Analogues Act.

2.

Fentanyl-related substances

(a)

Amendments

Section 202(c) of the Controlled Substances Act (21 U.S.C. 812(c)) is amended—

(1)

by adding at the end of subsection (b) of Schedule I the following:

(23)

Isobutyryl fentanyl.

(24)

Para-Methoxybutyrylfentanyl.

(25)

Valeryl fentanyl.

(26)

Cyclopentyl fentanyl.

(27)

Para-Chloroisobutyryl fentanyl.

; and

(2)

by adding at the end of Schedule I the following:

(e)
(1)

Unless specifically exempted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of fentanyl-related substances, or which contains their salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation.

(2)

In paragraph (1), the term fentanyl-related substances includes the following:

(A)

Any substance that is structurally related to fentanyl by one or more of the following modifications:

(i)

By replacement of the phenyl portion of the phenethyl group by any monocycle, whether or not further substituted in or on the monocycle.

(ii)

By substitution in or on the phenethyl group with alkyl, alkenyl, alkoxy, hydroxy, halo, haloalkyl, amino or nitro groups.

(iii)

By substitution in or on the piperidine ring with alkyl, alkenyl, alkoxy, ester, ether, hydroxy, halo, haloalkyl, amino or nitro groups.

(iv)

By replacement of the aniline ring with any aromatic monocycle whether or not further substituted in or on the aromatic monocycle.

(v)

By replacement of the N-propionyl group by another acyl group.

(B)

4′-Methyl acetyl fentanyl.

(C)

Crotonyl fentanyl.

(D)

2′-Fluoro ortho-fluorofentanyl.

(E)

Ortho-Methyl acetylfentanyl.

(F)

Thiofuranyl fentanyl.

(G)

Ortho-Fluorobutyryl fentanyl.

(H)

Ortho-Fluoroacryl fentanyl.

(I)

Beta-Methyl fentanyl.

(J)

Phenyl fentanyl.

(K)

Para-Methylfentanyl.

(L)

Beta′-Phenyl fentanyl.

(M)

Benzodioxole fentanyl.

.

(b)

Effective date

This Act shall take effect 1 day after the date of enactment of this Act.