S. 1410Senate117th Congress (2021-2023)In Committee

Protecting Americans from Fentanyl Trafficking Act of 2021

Sponsored by Tom CottonSen. Tom Cotton (R-AR)
Introduced April 28, 2021

AI-Generated Summary

Updated February 8, 2026 at 2:20 AM UTC

The Protecting Americans from Fentanyl Trafficking Act of 2021 makes permanent a temporary rule that places fentanyl‑related drugs into the most restrictive category of the Controlled Substances Act. It adds these substances to Schedule I, meaning they are considered to have a high potential for abuse and no accepted medical use. The change applies to any fentanyl‑related chemicals that meet the bill’s definition, affecting manufacturers, distributors, and law‑enforcement agencies that handle these drugs.

Key Provisions

  • Amends Schedule I of the Controlled Substances Act to include fentanyl‑related substances, covering their isomers, esters, ethers, salts, and related forms.
  • Defines a “fentanyl‑related substance” as any compound not listed in another schedule, not approved by the FDA, and that is structurally related to fentanyl through specific chemical modifications such as changes to the phenyl portion, phenethyl group, piperidine ring, aniline ring, or N‑propionyl group.

Legislative Activity

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1 earlier action
SenateIntro Referral Latest Action

Read twice and referred to the Committee on the Judiciary.

April 28, 2021

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SenateIntro Referral

Introduced in Senate

April 28, 2021

SenateIntro Referral

Read twice and referred to the Committee on the Judiciary.

April 28, 2021

Floor Debate

2 members

What members said about S. 1410 on the floor

1 Republican1 Democrat
Tom Cotton
Sen. Tom CottonR-AR · Apr 28, 2021

Madam President, sadly, the United States is in the midst of the deadliest drug epidemic in our Nation's history, caused by some of the deadliest drugs ever created. It appears that more than 80,000…

Cory A. Booker
Sen. Cory A. BookerD-NJ · Apr 28, 2021

Reserving the right to object. I am deeply grateful to my colleague and friend, the Senator from Arkansas, for bringing this to the floor of the U.S. Senate. There is an urgency he described that I…

Bill Text

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Introduced in SenateIssued April 28, 2021

II

117th CONGRESS

1st Session

S. 1410

IN THE SENATE OF THE UNITED STATES

April 28, 2021

Mr. Cotton introduced the following bill; which was read twice and referred to the Committee on the Judiciary

A BILL

To codify the temporary scheduling order for fentanyl-related substances by adding fentanyl-related substances to schedule I of the Controlled Substances Act.

1.

Short title

This Act may be cited as the Protecting Americans from Fentanyl Trafficking Act of 2021.

2.

Placement of fentanyl-related substances in schedule I

Schedule I of section 202(c) of the Controlled substances Act (21 U.S.C. 812(c)) is amended by adding at the end the following:

(e)
(1)

Fentanyl-related substances, including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers.

(2)

For purposes of paragraph (1), the term fentanyl-related substance means any substance that—

(A)

is not listed in another schedule;

(B)

has not been approved under section 505 of the Federal Food, Drug, and Cosmetic Act (21 U.S.C. 355) or granted an exemption for investigational use under subsection (i) of such section 505; and

(C)

is structurally related to fentanyl by—

(i)

replacement of the phenyl portion of the phenethyl group by any monocycle, whether or not further substituted in or on the monocycle;

(ii)

substitution in or on the phenethyl group with alkyl, alkenyl, alkoxyl, hydroxyl, halo, haloalkyl, amino, or nitro groups;

(iii)

substitution in or on the piperidine ring with alkyl, alkenyl, alkoxyl, ester, ether, hydroxyl, halo, haloalkyl, amino, or nitro groups;

(iv)

replacement of the aniline ring with any aromatic monocycle, whether or not further substituted in or on the aromatic monocycle; or

(v)

replacement of the N-propionyl group by another acyl group.

.