S. 339 – Federal Initiative to Guarantee Health by Targeting Fentanyl Act

AI-Generated Summary

Updated February 7, 2026 at 10:54 PM UTC

The bill amends the Controlled Substances Act to place fentanyl‑related substances into Schedule I, the category for drugs with high abuse potential and no accepted medical use. It also eliminates any statutory minimum prison term for offenses involving those substances. The changes affect anyone who manufactures, distributes, possesses, or uses fentanyl‑related compounds, as well as law‑enforcement and the courts.

Key Provisions

Adds fentanyl‑related substances, defined by specific chemical modifications, to Schedule I of the Controlled Substances Act.
Removes any mandatory minimum imprisonment requirement for violations involving those newly listed substances.

Legislative Activity

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1 earlier action

SenateIntro Referral Latest Action

Read twice and referred to the Committee on the Judiciary.

Judiciary Committee

February 22, 2021

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SenateIntro Referral

Introduced in Senate

February 22, 2021

SenateIntro Referral

Read twice and referred to the Committee on the Judiciary.

Judiciary Committee

February 22, 2021

Bill Text

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Introduced in SenateIssued February 22, 2021

II

117th CONGRESS

1st Session

S. 339

IN THE SENATE OF THE UNITED STATES

February 22, 2021

Mr. Portman (for himself and Mr. Manchin) introduced the following bill; which was read twice and referred to the Committee on the Judiciary

A BILL

To amend the Controlled Substances Act to list fentanyl-related substances as schedule I controlled substances, and for other purposes.

1.

Short title

This Act may be cited as the Federal Initiative to Guarantee Health by Targeting Fentanyl Act.

2.

Fentanyl-related substances

(a)

In general

Schedule I of section 202(c) of the Controlled Substances Act (21 U.S.C. 812(c)) is amended by adding at the end the following:

(e)

(1)

Unless specifically exempted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of fentanyl-related substances, or which contains their salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation.

(2)

In paragraph (1), the term fentanyl-related substances includes any substance that is structurally related to fentanyl by 1 or more of the following modifications:

(A)

By replacement of the phenyl portion of the phenethyl group by any monocycle, whether or not further substituted in or on the monocycle.

(B)

By substitution in or on the phenethyl group with alkyl, alkenyl, alkoxyl, hydroxyl, halo, haloalkyl, amino, or nitro groups.

(C)

By substitution in or on the piperidine ring with alkyl, alkenyl, alkoxyl, ester, ether, hydroxyl, halo, haloalkyl, amino, or nitro groups.

(D)

By replacement of the aniline ring with any aromatic monocycle whether or not further substituted in or on the aromatic monocycle.

(E)

By replacement of the N-propionyl group by another acyl group.

.

(b)

No minimum sentence

Section 401(b)(1)(C) of the Controlled Substances Act (21 U.S.C 841(b)(1)(C)) is amended by adding at the end the following: Any minimum term of imprisonment required to be imposed under this subparagraph shall not apply with respect to a controlled substance described in subsection (e)(1) of schedule I..