S. 1838Senate119th Congress (2025-2027)Passed Senate

DeOndra Dixon INCLUDE Project Act of 2026

Introduced May 21, 2025

AI-Generated Summary

Updated August 7, 2026 at 11:43 PM UTC

The DeOndra Dixon INCLUDE Project Act of 2026 amends the Public Health Service Act to establish a new NIH‑led program focused on Down syndrome research, training, and investigation. The law creates the INCLUDE Project to fund high‑impact studies across the lifespan, expand clinical trials, and improve understanding and treatment of co‑occurring conditions. It also sets up coordination among NIH institutes, stakeholder consultation, and regular reporting to Congress.

Key Provisions

  • Creates the “INCLUDE Project” (Investigation of Co‑occurring conditions across the Lifespan to Understand Down syndrome) within the NIH to fund research, training, and investigation on Down syndrome.
  • Funds high‑risk, high‑reward studies on how trisomy 21 affects development and health, and supports lifespan cohort studies to better understand Down syndrome and its co‑occurring conditions.
  • Expands clinical trials that include or target participants with Down syndrome, covering new biomedical, pharmacological, and therapeutic approaches to improve daily living.
  • Supports research into the biological mechanisms behind structural, functional, behavioral, and growth abnormalities in people with Down syndrome.
  • Promotes work on diagnosing and treating co‑occurring conditions—such as Alzheimer’s disease, dementia, and autoimmune disorders—by identifying biomarkers and risk factors.
  • Funds research, training, and activities aimed at improving the quality of life for individuals with Down syndrome and their families.
  • Requires NIH institutes and centers to coordinate their Down‑syndrome research, avoid duplication, and prioritize unique studies.
  • Mandates consultation with patient advocates and other stakeholders to ensure research meets the needs of the Down‑syndrome community.
  • Requires the NIH Director to submit biennial reports to Congress detailing the research conducted, the institutes involved, and any real‑world evidence generated for clinical care.

Legislative Activity

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7 earlier actions
HouseFloor Latest Action

Held at the desk.

August 10, 2026 • 11:10 AM

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SenateIntro Referral

Introduced in Senate

May 21, 2025

SenateIntro Referral

Read twice and referred to the Committee on Health, Education, Labor, and Pensions.

May 21, 2025

SenateCommittee

Senate Committee on Health, Education, Labor, and Pensions discharged by Unanimous Consent.

August 6, 2026

SenateFloor

Measure laid before Senate by unanimous consent. (consideration: CR S4495-4498)

August 6, 2026

SenateFloor

Passed Senate with an amendment by Voice Vote. (text of amendment in the nature of a substitute: CR S4495-4496)

August 6, 2026

SenateFloor

Message on Senate action sent to the House.

August 10, 2026

HouseFloor

Received in the House.

August 10, 2026 • 11:02 AM

HouseFloor

Held at the desk.

August 10, 2026 • 11:10 AM

Floor Debate

24 members

What members said about S. 1838 on the floor

9 Republicans15 Democrats
Raphael G. Warnock
Sen. Raphael G. WarnockD-GA · Mar 18, 2026

Mr. President, I am so grateful for the remarks of my colleague and friend from the great State of Massachusetts and for his voice on this very important issue. I rise today as a child of the Civil…

Elizabeth Warren
Sen. Elizabeth WarrenD-MA · Mar 18, 2026

Mr. President, I very much appreciate the Reverend Senator Warnock and his reminder that questions about voting in America are moral questions, they are historic questions, and they are questions…

Lindsey Graham
Sen. Lindsey GrahamR-SC · Mar 18, 2026

Mr. President, you are entitled to your opinion. This is a free country. Whether you like President Trump or not is up to you. Your view of the war is up to you. But you are not entitled to your…

Chris Van Hollen
Sen. Chris Van HollenD-MD · Mar 18, 2026

Mr. President, I think all of us know here in the Senate that Senators have the ability to write the titles of their own bills. You can give a bill whatever name you want, whether it is accurate and…

Martin Heinrich
Sen. Martin HeinrichD-NM · Mar 18, 2026

Mr. President, I ask unanimous consent that the order for the quorum call be rescinded. Mr. President, nearly 5 years ago, I stood on the Senate floor, and I said that we were ``facing the most…

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Cory A. Booker
Sen. Cory A. BookerD-NJ · Mar 18, 2026

Mr. President, I am grateful for the recognition. I think we should set the scene very clearly. During the last 2 weeks since we voted on the War Powers Resolution, led in a bipartisan manner by…

Charles E. Schumer
Sen. Charles E. SchumerD-NY · Mar 18, 2026

Mr. President, there are so many issues Senate Republicans could be working with us on this week that Americans actually care about. Republicans could focus on whether Americans can afford groceries…

Richard J. Durbin
Sen. Richard J. DurbinD-IL · Aug 6, 2026

Mr. President, a few years ago, I met a young woman who lives in the Chicago suburbs. She told me a story of her college career and what it led to. It was something I had never heard before. Her…

Jeanne Shaheen
Sen. Jeanne ShaheenD-NH · Mar 18, 2026

Mr. President, I ask unanimous consent that the order for the quorum call be rescinded. Mr. President, I came to the floor this afternoon in opposition to the SAVE Act. And I must admit, listening to…

James Lankford
Sen. James LankfordR-OK · Mar 18, 2026

Mr. President, reserving the right to object, I do thank my colleague for coming to the floor to be able to talk about this today. He and I are both on airplanes a lot. The comment that has been made…

Chuck Grassley
Sen. Chuck GrassleyR-IA · Mar 18, 2026

Mr. President, I thank Senator Cornyn for his strong remarks in support of honest elections. I come to the floor for a different reason. But in support of what Senator Cornyn said, I want people to…

Tom Cotton
Sen. Tom CottonR-AR · Mar 18, 2026

Mr. President, one of the most despicable pieces of legislation, an attack on our sacred right to vote, a voter suppression bill--these are just some of the hysterical things that Democrats have said…

Edward J. Markey
Sen. Edward J. MarkeyD-MA · Mar 18, 2026

Mr. President, the Republican majority, representing the views of the President here on the floor of the Senate, are trying to engage not in a save-democracy but a steal-democracy movement. That is…

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James E. Risch
Sen. James E. RischR-ID · Mar 18, 2026

Mr. President, I come to the floor today in strong support of a bill that I have supported from the very beginning, that being the SAVE America Act. The SAVE America Act is common sense. At its core,…

Adam B. Schiff
Sen. Adam B. SchiffD-CA · Mar 18, 2026

Mr. President, I thank Senator Booker for his extraordinary leadership on this War Powers Resolution. Some of my colleagues may not know this, but I was raised in a divided household. My father was a…

Marsha Blackburn
Sen. Marsha BlackburnR-TN · Mar 18, 2026

Mr. President, I am so grateful that we are having this discussion on the floor. I will note that our friends across the aisle wanted a unanimous consent just to pass pay for TSA workers. I think it…

Tammy Duckworth
Sen. Tammy DuckworthD-IL · Mar 18, 2026

Mr. President, it wasn't too long ago that Donald Trump won the 2024 election, in large part, due to his promise to get our Nation out of foreign wars and bring prices down for Americans across this…

Christopher Murphy
Sen. Christopher MurphyD-CT · Mar 18, 2026

Mr. President, I am humbled to follow my colleague from Illinois. No one is more articulate on the question of the cost of war than Senator Duckworth, and I agree with everything that she said about…

Ashley Moody
Sen. Ashley MoodyR-FL · Mar 18, 2026

Mr. President, I know how hard the Presiding Officer and so many of our colleagues have worked to get the SAVE America Act to the floor. I want to thank the Presiding Officer because more than 200…

Tim Kaine
Sen. Tim KaineD-VA · Mar 18, 2026

Mr. President, I am glad to join my colleagues on the floor in support of Senator Booker's War Powers Resolution. For those who wonder what a War Powers Resolution is, it is pretty simple. It is a…

Ron Johnson
Sen. Ron JohnsonR-WI · Mar 18, 2026

Mr. President, I would just like to offer a few words of rebuttal for the Democratic leader. He talked about high oil prices. He didn't mention the fact that when President Biden was in office and…

Bill Cassidy
Sen. Bill CassidyR-LA · Aug 6, 2026

Mr. President, I ask unanimous consent that the order for the quorum call be rescinded. Mr. President, as the Presiding Officer knows, one of the privileges of being a Senator is the opportunity to…

John W. Hickenlooper
Sen. John W. HickenlooperD-CO · Aug 6, 2026

Mr. President, I ask unanimous consent for the Senate to pass S. 1838, the DeOndra Dixon INCLUDE Project Act. Thousands of Americans live with Down syndrome, and yet research has been underfunded for…

Tammy Baldwin
Sen. Tammy BaldwinD-WI · Mar 18, 2026

Mr. President, I rise today on behalf of the majority of Americans who oppose President Trump's war in Iran. I also rise on behalf of the families who just want him to fulfill his promises to lower…

Bill Text

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Engrossed in SenateIssued August 6, 2026

119th CONGRESS

2d Session

S. 1838

AN ACT

To amend the Public Health Service Act to authorize the Secretary of Health and Human Services to carry out a program of research, training, and investigation related to Down syndrome, and for other purposes.

1.

Short title

This Act may be cited as the DeOndra Dixon INCLUDE Project Act of 2026.

2.

DeOndra Dixon INCLUDE Project

Part B of title IV of the Public Health Service Act (42 U.S.C. 284 et seq.) is amended by adding at the end the following:

409K.

Down syndrome research

(a)

In general

The Director of NIH shall carry out a program of research, training, and investigation related to Down syndrome to be known as the INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE Project or the INCLUDE Project.

(b)

Program elements

The program under subsection (a) shall include—

(1)

high-risk, high-reward research on the effects of trisomy 21 on human development and health;

(2)

promoting research for participants with Down syndrome across the lifespan, including cohort studies to facilitate improved understanding of Down syndrome and co-occurring conditions and development of new interventions;

(3)

expanding the number of clinical trials that are inclusive of, or expressly for, participants with Down syndrome, including novel biomedical and pharmacological interventions and other therapies designed to promote or enhance activities of daily living;

(4)

research on the biological mechanisms in individuals with Down syndrome pertaining to structural, functional, and behavioral anomalies and dysfunction as well as stunted growth;

(5)

supporting research to improve diagnosis and treatment of conditions co-occurring with Down syndrome, including the identification of biomarkers related to risk factors, diagnosis, and clinical research and therapeutics;

(6)

research on the causes of increased prevalence, and concurrent treatment, of co-occurring conditions, such as Alzheimer’s disease and related dementias and autoimmunity, in individuals with Down syndrome; and

(7)

research, training, and investigation on improving the quality of life of individuals with Down syndrome and their families.

(c)

Coordination; prioritizing nonduplicative research

The Director of NIH shall ensure that—

(1)

the programs and activities of the institutes and centers of the National Institutes of Health relating to Down syndrome and co-occurring conditions are coordinated, including through the Office of the Director of NIH and priority-setting reviews conducted pursuant to section 402(b)(3); and

(2)

such institutes and centers, prioritize, as appropriate, Down syndrome research that does not duplicate existing research activities of the National Institutes of Health.

(d)

Consultation with stakeholders

In carrying out activities under this section, the Director of NIH shall, as appropriate and to the maximum extent feasible, consult with relevant stakeholders, including patient advocates, to ensure that such activities take into consideration the needs of individuals with Down syndrome.

(e)

Biennial reports to Congress

(1)

In general

The Director of NIH shall submit, on a biennial basis, to the Committee on Energy and Commerce and the Subcommittee on Labor, Health and Human Services, Education, and Related Agencies of the Committee on Appropriations of the House of Representatives and the Committee on Health, Education, Labor, and Pensions and the Subcommittee on Labor, Health and Human Services, Education, and Related Agencies of the Committee on Appropriations of the Senate, a report that catalogs the research conducted or supported under this section.

(2)

Contents

Each report under paragraph (1) shall include—

(A)

identification of the institute or center involved;

(B)

a statement of whether the research is or was being carried out directly by such institute or center or by multiple institutes and centers; and

(C)

identification of any resulting real-world evidence that is or may be used for clinical research and medical care for patients with Down syndrome.

.

Passed the Senate August 6, 2026.

Secretary