Mr. Speaker, as a physician, I know that respected scientists believe that misrepresentations and exaggerated claims in this debate are not only scientifically irresponsible, they are deceptive and cruel to millions of patients and their…
Mr. Speaker, as a physician, I know that respected scientists believe that misrepresentations and exaggerated claims in this debate are not only scientifically irresponsible, they are deceptive and cruel to millions of patients and their families who hope desperately for cures.
It seems to me that there is one unmistakable fact. Many in our society have sincere, heartfelt, passionate, ethical questions, worthy of our respect, regarding the scientific or medical use of embryonic stem cells. If our goal is truly to cure diseases and help patients, science tells us that today the use of adult and cord stem cells has successfully treated or holds real potential for treating nearly 60 diseases. The same cannot be said for embryonic stem cells, and adult stem cells carry none of the ethical questions or dilemma of embryonic stem cells.
I support stem cell research, active, aggressive and scientifically based, with respect for the difficult ethical questions we face today. I urge my colleagues to join me in respecting science, in respecting ethical concerns. If we do, we will recognize that stem cell research and treatment of disease should actively proceed with those adult and cord stem cells that are providing and will increasingly provide excellent and exciting cures for patients in need.
Mr. Speaker, as a physician I'm certain of one thing: Science is not Republican or Democrat, Science is not conservative or liberal. Science is science. Decisions in science should be based on the scientific method--a standardized method of evaluation and implementation of a solution or treatment of a disease.
When followed, it allows for the greatest amount of critical thinking about any issue. If followed, it results in the best outcome. This would be true in public policy as well. If not followed in a legislative body, then decisions tend to be made based upon who has the largest group of supporters or greatest passion and emotion. Now there is nothing wrong with numbers, passion or emotion, it just may not get you to the correct solution--especially in the scientific arena.
There has been significant misrepresentation of science today and in this debate, because ``science is not a policy or a political program. Science is a systematic method for developing and testing hypotheses about the physical world. It does not promise miracle cures based on scanty evidence. . . . statements . . . made regarding the purported medical applications of embryonic stem cells reach far beyond any credible evidence, ignoring the limited state of our knowledge about embryonic stem cells and the advances in other areas of research that may render use of these cells unnecessary for many applications. To make such exaggerated claims, at
this stage of our knowledge, is not only scientifically irresponsible-- it is deceptive and cruel to millions of patients and their families who hope desperately for cures and have come to rely on the scientific community for accurate information. . . . Non-embryonic stem cells'' on the other hand have a history ``very different from that of embryonic stem cells.'' Cord and adult stem cells are ``Producing undoubted clinical benefits and . . . (b) one marrow transplants'' have benefited ``patients with various forms of cancer for many years before it was understood that the active ingredients in these transplants are stem cells. . . . Use of these cells poses no serious ethical problem, and may avoid all problems of tissue rejection if stem cells can be obtained from a patient for use in that same patient. . . . In contrast to embryonic stem cells, adult stem cells are in established or experimental use to treat human patients with several dozen conditions. . . . They have been or are being assessed in human trials for treatment of spinal cord injury, Parkinson's disease, stroke, cardiac damage, multiple sclerosis,'' juvenile diabetes ``and so on. . . .
``Therefore . . . to declare that'' embryonic stem cell research ``will . . . receive any particular amount of federal funding, regardless of future evidence or the usual scientific peer review process--is . . . irresponsible. It is, in fact, a subordination of science to ideology.
``Because politicians, biotechnology interests and even some scientists have publicly exaggerated the ``promise'' of embryonic stem cells, public perceptions of this avenue have become skewed and unrealistic. Politicians may hope to benefit from these false hopes to win elections. . . . The scientific and medical professions have no such luxury. When desperate patients discover that they have been subjected to a salesman's pitch rather than an objective and candid assessment of possibilities, we have reason to fear public backlash against the credibility of our profession. We urge you not to exacerbate this problem now by repeating false promises that exploit patients' hopes for political gain.''
I have quoted from a letter signed by 57 scientists--MD's and PhD's-- written during last year's presidential campaign. It expressed real concern about a cavalier public posture and policy during a debate on such a sensitive ethical matter.
It seems to me that there is one unmistakable fact: Many in our society have sincere, heartfelt, passionate, ethical questions, worthy of our respect, regarding the scientific or medical use of ES cells.
If our goal is truly to cure diseases and help patients, science tells us that today the use of adult and cord stem cells has successfully treated or holds real potential for treating nearly 60 diseases. The same cannot be said for ES cells.
And adult stem cells carry none of the ethical questions or dilemma of ES cells.
I support stem cell research--active, aggressive, scientifically based--with respect for the difficult ethical questions we face today.
I urge my colleagues to join me in respecting current science--in respecting ethical concerns. If we do, we will recognize that stem cell research and treatment of disease should actively proceed with those adult and cord stem cells that are providing and will increasingly provide excellent and exciting cures for patients in need.
October 27, 2004.
Senator John F. Kerry,
John Kerry for President, Washington, DC.
Dear Senator Kerry: Recently you have made the promotion of
embryonic stem cell research, including the cloning of human
embryos for research purposes, into a centerpiece of your
campaign. You have said you will make such research a ``top
priority'' for government, academia and medicine (Los Angeles
Times, 10/17/04). You have even equated support for this
research with respect for ``science,'' and said that science
must be freed from ``ideology'' to produce miracle cures for
numerous diseases.
As professionals trained in the life sciences we are
alarmed at these statements.
First, your statements misrepresent science. In itself,
science is not a policy or a political program. Science is a
systematic method for developing and testing hypotheses about
the physical world. It does not ``promise'' miracle cures
based on scanty evidence. When scientists make such
assertions, they are acting as individuals, out of their own
personal faith and hopes, not as the voice of ``science''. If
such scientists allow their individual faith in the future of
embryonic stem cell research to be interpreted as a reliable
prediction of the outcome of this research, they are acting
irresponsibly.
Second, it is no mere ``ideology'' to be concerned about
the possible misuse of humans in scientific research. Federal
bioethics advisory groups, serving under both Democratic and
Republican presidents, have affirmed that the human embryo is
a developing form of human life that deserves respect. Indeed
you have said that human life begins at conception, that
fertilization produces a ``human being.'' To equate concern
for these beings with mere ``ideology'' is to dismiss the
entire history of efforts to protect human subjects from
research abuse.
Third, the statements you have made regarding the purported
medical applications of embryonic stem cells reach far beyond
any credible evidence, ignoring the limited state of our
knowledge about embryonic stem cells and the advances in
other areas of research that may render use of these cells
unnecessary for many applications. To make such exaggerated
claims, at this stage of our knowledge, is not only
scientifically irresponsible--it is deceptive and cruel to
millions of patients and their families who hope desperately
for cures and have come to rely on the scientific community
for accurate information.
What does science tell us about embryonic stem cells? The
facts can be summed up as follows:
At present these cells can be obtained only by destroying
live human embryos at the blastocyst (4-7 days old) stage.
They proliferate rapidly and are extremely versatile,
ultimately capable (in an embryonic environment) of forming
any kind of cell found in the developed human body. Yet
there is scant scientific evidence that embryonic stem
cells will form normal tissues in a culture dish, and the
very versatility of these cells is now known to be a
disadvantage as well--embryonic stem cells are difficult
to develop into a stable cell line, spontaneously
accumulate genetic abnormalities in culture, and are prone
to uncontrollable growth and tumor formation when placed
in animals.
Almost 25 years of research using mouse embryonic stem
cells have produced limited indications of clinical benefit
in some animals, as well as indications of serious and
potentially lethal side-effects. Based on this evidence,
claims of a safe and reliable treatment for any disease in
humans are premature at best.
Embryonic stem cells obtained by destroying cloned human
embryos pose an additional ethical issue--that of creating
human lives solely to destroy them for research--and may pose
added practical problems as well. The cloning process is now
known to produce many problems of chaotic gene expression,
and this may affect the usefulness and safety of these cells.
Nor is it proven that cloning will prevent all rejection of
embryonic stem cells, as even genetically matched stem cells
from cloning are sometimes rejected by animal hosts. Some
animal trials in research cloning have required placing
cloned embryos in a womb and developing them to the fetal
stage, then destroying them for their more developed tissues,
to provide clinical benefit--surely an approach that poses
horrific ethical issues if applied to humans.
Non-embryonic stem cells have also received increasing
scientific attention. Here the trajectory has been very
different from that of embryonic stem cells: Instead of
developing these cells and deducing that they may someday
have a clinical use, researchers have discovered them
producing undoubted clinical benefits and then sought to
better understand how and why they work so they can be put to
more uses. Bone marrow transplants were benefiting patients
with various forms of cancer for many years before it was
understood that the active ingredients in these transplants
are stem cells. Non-embryonic stem cells have been discovered
in many unexpected tissues--in blood, nerve, fat, skin,
muscle, umbilical cord blood, placenta, even dental pulp--and
dozens of studies indicate that they are far more versatile
than once thought. Use of these cells poses no serious
ethical problem, and may avoid all problems of tissue
rejection if stem cells can be obtained from a patient for
use in that same patient. Clinical use of non-embryonic stem
cells has grown greatly in recent years. In contrast to
embryonic stem cells, adult stem cells are in established or
experimental use to treat human patients with several dozen
conditions, according to the National Institutes of Health
and the National Marrow Donor Program (Cong. Record,
September 9, 2004, pages H6956-7). They have been or are
being assessed in human trials for treatment of spinal cord
injury, Parkinson's disease, stroke, cardiac damage, multiple
sclerosis, and so on. The results of these experimental
trials will help us better assess the medical prospects for
stem cell therapies.
In the case of many conditions, advances are likely to come
from sources other than any kind of stem cell. For example,
there is a strong scientific consensus that complex diseases
such as Alzheimer's are unlikely to be treated by any stem
cell therapy. When asked recently why so many people
nonetheless believe that embryonic stem cells will provide a
cure for Alzheimer's disease, NIH stem cell expert Ron McKay
commented that ``people need a fairy tale'' (Washington Post,
June 10, 2004, page A3). Similarly, autoimmune diseases like
juvenile diabetes, lupus and MS are unlikely to benefit from
simple addition of new cells unless the underlying
problem--a faulty immune system that attacks the body's
own cells as though they were foreign invaders--is
corrected.
In short, embryonic stem cells pose one especially
controversial avenue toward understanding and (perhaps)
someday treating various degenerative diseases. Based on the
available evidence, no one can predict with certainty whether
they will ever produce clinical benefits--much less whether
they will produce benefits unobtainable by other, less
ethically problematic means.
Therefore, to turn this one approach into a political
campaign--even more, to declare that it will be a ``top
priority'' or receive
any particular amount of federal funding, regardless of
future evidence or the usual scientific peer review process--
is, in our view, irresponsible. It is, in fact, a
subordination of science to ideology.
Because politicians, biotechnology interests and even some
scientists have publicly exaggerated the ``promise'' of
embryonic stem cells, public perceptions of this avenue have
become skewed and unrealistic. Politicians may hope to
benefit from these false hopes to win elections, knowing that
the collision of these hopes with reality will come only
after they win their races. The scientific and medical
professions have no such luxury. When desperate patients
discover that they have been subjected to a salesman's pitch
rather than an objective and candid assessment of
possibilities, we have reason to fear a public backlash
against the credibility of our professions. We urge you not
to exacerbate this problem now by repeating false promises
that exploit patients' hopes for political gain.
Signed,
Rodney D. Adam, M.D., Professor of Medicine and
Microbiology/Immunology, University of Arizona College of
Medicine.
Michael J. Behe, Ph.D., Professor of Biological Sciences,
Lehigh University.
Thomas G. Benoit, Ph.D., Professor and Chairman of Biology,
McMurry University, Abilene, TX.
David L. Bolender, Ph.D., Department of Cell Biology,
Neurobiology and Anatomy, Medical College of Wisconsin.
Daniel L. Burden, Ph.D., Assistant Professor of Chemistry,
Wheaton College.
William J. Burke, M.D., Ph.D., Professor in Neurology,
Associate Professor in Medicine, Associate Professor in
Neurobiology, Saint Louis University Medical Center.
Mark W. Burket, M.D., Professor of Medicine, Division of
Cardiology, Medical College of Ohio.
W. Malcolm Byrnes, Ph.D., Assistant Professor, Department
of Biochemistry and Molecular Biology, Howard University
College of Medicine.
Steven Calvin, M.D., Assistant Professor of OB/GYN and
Women's Health, Co-Chair, Program in Human Rights in
Medicine, University of Minnesota School of Medicine.
James Carroll, M.D., Professor of Neurology, Pediatrics,
and Biochemistry and Molecular Biology, Medical College of
Georgia.
John R. Chaffee, M.D., Assistant Clinical Professor,
Department of Family Medicine, University of Washington.
Robert Chasuk, M.D., Clinical Assistant Professor,
Department of Family Medicine, Tulane University.
William P. Cheshire, Jr., M.D., Associate Professor of
Neurology, Mayo Clinic.
Richard A. Chole, M.D., Ph.D., Professor and Head of
Otolaryngology, Washington University in St. Louis, School of
Medicine.
Maureen L. Condic, Ph.D., Associate Professor, Department
of Neurobiology and Anatomy, University of Utah School of
Medicine.
Keith A. Crist, Ph.D., Associate Professor, Department of
Surgery, Medical College of Ohio.
Keith A. Crutcher, Ph.D., Professor, Department of
Neurosurgery, University of Cincinnati Medical Center.
Frank Dennehy, M.D., FAAFP, Assistant Clinical Professor of
Family Medicine, Virginia Commonwealth University.
Kenneth J. Dormer, M.S., Ph.D., Professor of Physiology,
University of Oklahoma College of Medicine.
Lawrence W. Elmer, M.D., Ph.D., Associate Professor, Dept.
of Neurology Director, Parkinson's Disease and Movement
Disorder Program, Medical Director, Center for Neurological
Disorders, Medical College of Ohio.
Kevin T. FitzGerald, SJ, Ph.D., David P. Lauler Chair in
Catholic Health Care Ethics, Research Associate Professor,
Department of Oncology, Georgetown University Medical Center.
Raymond F. Gasser, Ph.D., Professor, Department of Cell
Biology and Anatomy, Louisiana State University School of
Medicine.
Hans Geisler, M.D., Clinical Professor of Obstetrics and
Gynecology, Indiana University Medical Center.
Donald A. Godfrey, Ph.D., Professor of Otolaryngology,
Department of Surgery, Medical College of Ohio.
Samuel Hensley, M.D., Assistant Clinical Professor, School
of Medicine, University of Mississippi.
David C. Hess, M.D., Professor and Chairman, Department of
Neurology, Medical College of Georgia.
Paul J. Hoehner, M.D., MA, Ph.D., FAHA Associate Professor,
Department of Anesthesiology, The University of Virginia
School of Medicine.
C. Christopher Hook, M.D., Consultant in Hematology and
Internal Medicine, Assistant Professor of Medicine, Mayo
Clinic College of Medicine.
Elizabeth A. Johnson, M.D., Consultant, Hematology/
Oncology, Mayo Clinic Jacksonville Assistant Professor of
Oncology, Mayo Clinic College of Medicine.
Nancy L. Jones, Ph.D., Associate Professor of Pathology,
Wake Forest University School of Medicine.
C. Ward Kischer, Ph.D., Emeritus Professor, Cell Biology
and Anatomy, Specialty in Human Embryology, University of
Arizona College of Medicine.
Kirsten J Lampi, M.S., Ph.D., Associate Professor of
Integrative Biosciences, School of Dentistry, Oregon Health
Sciences University.
John I. Lane, M.D., Assistant Professor of Radiology, Mayo
Clinic School of Medicine.
David L. Larson, M.D., Professor and Chairman, Department
of Plastic Surgery, Medical College of Wisconsin.
Micheline Mathews-Roth, M.D., Associate Professor of
Medicine, Harvard Medical School.
Roger R. Markwald, Ph.D., Professor and Chair, Department
of Cell Biology and Anatomy, Medical University of South
Carolina.
Victor E. Marquez, Ph.D., Chief, Laboratory of Medicinal
Chemistry, Center for Cancer Research, National Cancer
Institute, Frederick, Maryland.
Ralph P. Miech, M.D., Ph.D., Associate Professor Emeritus,
Department of Molecular Pharmacology, Physiology &
Biotechnology, Brown University School of Medicine.
Mary Ann Myers, M.D., Associate Professor, Medical College
of Ohio.
Rimas J. Orentas, Ph.D., Associate Professor of Pediatrics,
Hematology-Oncology Section, Medical College of Wisconsin.
Robert D. Orr, M.D., CM, Clinical Ethicist and Professor,
University of Vermont College of Medicine.
Jean D. Peduzzi-Nelson, Ph.D., Research Associate
Professor, Department of Visual Sciences, University of
Alabama at Birmingham.
Edmund D. Pellegrino, M.D., Emeritus Professor, Medicine
and Medical Ethics, Center for Clinical Bioethics, Georgetown
University Medical Center.
John A. Petros, M.D., Associate Professor, Urology and
Pathology, Emory University.
David A. Prentice, Ph.D., Affiliated Scholar, Center for
Clinical Bioethics, Georgetown University Medical Center.
Paul J. Ranalli, M.D., FRCPC, Lecturer, Division of
Neurology, Department of Medicine, University of Toronto.
John F. Rebhun, Ph.D., Adjunct Scientist, Indiana
University School of Medicine.
Leonard P. Rybak, M.D., Ph.D., Professor of Surgery,
Southern Illinois University School of Medicine.
Dwayne D. Simmons, Ph.D., Director, Inner Ear Research Core
Center, Department of Otolaryngology, Washington University
School of Medicine.
Joseph B. Stanford, M.D., MSPH, Associate Professor, Family
and Preventive Medicine, University of Utah.
John M. Templeton, Jr., M.D., FACS, Adjunct Professor of
Pediatric Surgery, University of Pennsylvania School of
Medicine.
Claire Thuning-Roberson, Ph.D., Vice President, Product
Development and Compliance, Sunol Molecular Corporation,
Miramar, Florida.
Anton-Lewis Usala, M.D., Chief Executive Officer and
Medical Director, Clinical Trial Management Group,
Greenville, North Carolina.
Richard A. Watson, M.D., Professor of Urologic Surgery, The
University of Medicine and Dentistry of New Jersey Medical
School.
Dennis D. Weisenburger, M.D., Director of Hematopathology,
Dept of Pathology and Microbiology, University of Nebraska
School of Medicine.
H. Joseph Yost, PhD., Professor of Oncological Sciences,
University of Utah.
Joseph R. Zanga, M.D., FAAP, FCP, President, American
College of Pediatricians, Professor of Pediatrics, Brody
School of Medicine, East Carolina University.