H.R. 2209House117th Congress (2021-2023)In Committee

Stopping Overdoses of Fentanyl Analogues Act

Introduced March 26, 2021

AI-Generated Summary

Updated February 8, 2026 at 1:05 AM UTC

The Stopping Overdoses of Fentanyl Analogues Act amends the Controlled Substances Act to place a range of fentanyl‑related chemicals into Schedule I, the category for substances with high abuse potential and no accepted medical use. It adds several specific fentanyl analogues to the schedule and creates a broad definition that captures any material containing these substances or their salts, isomers, or derivatives. The change affects manufacturers, distributors, and anyone handling these chemicals, making them subject to the strictest regulatory controls.

Key Provisions

  • Adds five named fentanyl analogues (Isobutyryl fentanyl, Para‑Methoxybutyrylfentanyl, Valeryl fentanyl, Cyclopentyl fentanyl, Para‑Chloroisobutyryl fentanyl) to Schedule I.
  • Defines “fentanyl‑related substances” to include any compound structurally related to fentanyl by specified chemical modifications and lists additional specific analogues (e.g., 4'-Methyl acetyl fentanyl, Crotonyl fentanyl, etc.).
  • States that any material, mixture, or preparation containing any fentanyl‑related substance—or its salts, isomers, or salts of isomers—is automatically placed in Schedule I unless specifically exempted.

Legislative Activity

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3 earlier actions
HouseCommittee Latest Action

Referred to the Subcommittee on Crime, Terrorism, and Homeland Security.

October 19, 2021

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HouseIntro Referral

Introduced in House

March 26, 2021

HouseIntro Referral

Referred to the Committee on Energy and Commerce, and in addition to the Committee on the Judiciary, for a period to be subsequently determined by the Speaker, in each case for consideration of such provisions as fall within the jurisdiction of the committee concerned.

March 26, 2021

HouseCommittee

Referred to the Subcommittee on Health.

March 29, 2021

HouseCommittee

Referred to the Subcommittee on Crime, Terrorism, and Homeland Security.

October 19, 2021

Bill Text

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Introduced in HouseIssued March 26, 2021

I

117th CONGRESS

1st Session

H. R. 2209

IN THE HOUSE OF REPRESENTATIVES

March 26, 2021

Mr. Fitzgerald (for himself, Mrs. Hinson, and Mr. Grothman) introduced the following bill; which was referred to the Committee on Energy and Commerce, and in addition to the Committee on the Judiciary, for a period to be subsequently determined by the Speaker, in each case for consideration of such provisions as fall within the jurisdiction of the committee concerned

A BILL

To amend the Controlled Substances Act to list fentanyl-related substances as schedule I controlled substances.

1.

Short title

This Act may be cited as the Stopping Overdoses of Fentanyl Analogues Act.

2.

Fentanyl-related substances

Section 202(c) of the Controlled Substances Act (21 U.S.C. 812) is amended—

(1)

by adding at the end of subsection (b) of Schedule I the following:

(23)

Isobutyryl fentanyl.

(24)

Para-Methoxybutyrylfentanyl.

(25)

Valeryl fentanyl.

(26)

Cyclopentyl fentanyl.

(27)

Para-Chloroisobutyryl fentanyl.

; and

(2)

by adding at the end of Schedule I the following:

(e)
(1)

Unless specifically exempted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of fentanyl-related substances, or which contains their salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation.

(2)

In paragraph (1), the term fentanyl-related substances includes the following:

(A)

Any substance that is structurally related to fentanyl by one or more of the following modifications:

(i)

By replacement of the phenyl portion of the phenethyl group by any monocycle, whether or not further substituted in or on the monocycle.

(ii)

By substitution in or on the phenethyl group with alkyl, alkenyl, alkoxy, hydroxy, halo, haloalkyl, amino or nitro groups.

(iii)

By substitution in or on the piperidine ring with alkyl, alkenyl, alkoxy, ester, ether, hydroxy, halo, haloalkyl, amino or nitro groups.

(iv)

By replacement of the aniline ring with any aromatic monocycle whether or not further substituted in or on the aromatic monocycle.

(v)

By replacement of the N-propionyl group by another acyl group.

(B)

4′-Methyl acetyl fentanyl.

(C)

Crotonyl fentanyl.

(D)

2′-Fluoro ortho-fluorofentanyl.

(E)

Ortho-Methyl acetylfentanyl.

(F)

Thiofuranyl fentanyl.

(G)

Ortho-Fluorobutyryl fentanyl.

(H)

Ortho-Fluoroacryl fentanyl.

(I)

Beta-Methyl fentanyl.

(J)

Phenyl fentanyl.

(K)

Para-Methylfentanyl.

(L)

Beta′-Phenyl fentanyl.

(M)

Benzodioxole fentanyl.

.

This Act shall take effect one day after the date of enactment.