Mr. Speaker, Mississippi lost a research treasure last week with the passing of Dr. Arthur C. Guyton. His is a legacy of medical excellence going beyond Mississippi and beyond America to be recognized internationally for his gifts to…
Mr. Speaker, Mississippi lost a research treasure last week with the passing of Dr. Arthur C. Guyton. His is a legacy of medical excellence going beyond Mississippi and beyond America to be recognized internationally for his gifts to science and education.
He began his life in Oxford, Mississippi, on September 8, 1919, born to the late Dr. and Mrs. Billy S. Guyton. His father--an eye, ear, nose and throat specialist--was also dean of the two-year medical school on the Oxford campus. His mother, Kate, had taught mathematics and physics as a missionary in China.
He graduated from University High School with the highest academic average in his class and entered Ole Miss in 1936, completed his undergraduate work in three years, and again graduated at the top of his class.
As a medical student at Harvard, his idea of creating a way to measure and differentiate ions in solutions resulted in a professor turning over an entire lab to the promising young scientist. His senior year in medical school, he and his future wife Ruth Weigle began a serious courtship which culminated in marriage on June 12, 1943.
He began a surgical internship at Massachusetts General Hospital shortly after his marriage. His training was interrupted by a call to serve in the US Navy at the National Naval Medical Center in Bethesda and later at Camp Detrick, Maryland, where his work earned him an Army Commendation Citation.
After World War II ended, he returned to Massachusetts General to complete his residency. Less than a year later, he was stricken with polio which would leave his right leg and shoulder paralyzed.
During a nine-month recovery at Warm Springs, Georgia, he designed a special leg brace, a hoist for moving patients from bed to chair to bathtub, and a motorized wheelchair controlled by an electric ``joy stick.'' For these devices, he later received the U.S. Presidential Citation for the Development of Aids for the Handicapped in 1956.
In 1947, the Guytons moved back to Oxford where he taught pharmacology in the two year medical school. In 1948, he was named chairman of the Department of Physiology and Biophysics.
Modern research on and treatments of hypertension stand on the early work of Dr. Guyton. In the 50s, he described the ``permissive'' heart to explain cardiac output. The heart would pump only what was delivered to it through the veins. When body tissues need extra blood flow to carry required oxygen and other nutrients, the blood vessels in those tissues expand or dilate, to allow increased flow. The control of cardiac output, he decided, was vested in the periphery. This completely overturned the conventional wisdom that the heart itself controlled cardiac output.
A little later, he succeeded in measuring the pressure of the interstitium, the fluid between cells which makes up about one-sixth of the body. No one had been able to measure it before, and few scientists were ready to accept Dr. Guyton's finding of a negative, or subatmospheric, pressure. In 1966, an early computer model gave Dr. Guyton the answer to the question he'd been asking since he was a medical student. He wanted to show the effect of an increase in fluid volume and had predicted that the extra volume would cause an initial rise in pressure which would then fall back part way toward normal. That didn't happen. The pressure fell all the way back to normal. This led to the ``infinite gain'' theory which said that fluid volume control by the kidney can be so powerful as a longterm regulator of blood pressure that other systems can only regulate pressure short-term and will eventually be overpowered by the key controller. These revolutionary theories flew in the face of conventional wisdom, but time and the research of thousands, has vindicated Dr. Guyton.
His now famous and widely used textbook, Textbook of Medical Physiology, had its beginnings in Oxford. He decided that the text the students were using was unsatisfactory, and he began reading in diverse areas of physiology. In summarizing his reading, he wrote handouts for each section of the course and realized he had the core of a complete textbook. In the decades since, it has become the best selling physiology text in the world and quite possibly the most widely used medical textbook of any kind. In addition he has published hundreds of papers sharing the results of his research. And yet he always had time for students--for the medical students who had trouble understanding a portion of their lecture and for the graduate students who came from all over the world to study with the famous Dr. Guyton.
The legacy of Arthur Guyton goes beyond his contributions to science and mankind. He
and his wife reared ten children, all doctors: Dr. David L. Guyton, Professor of Ophthalmology, Johns Hopkins University School of Medicine; Dr. Robert A. Guyton, Professor of Surgery and Chief of the Cardiothoracic Division, Emory University, School of Medicine; Dr. John R. Guyton, Associate Professor of Medicine, Duke University; Dr. Steven W. Guyton, cardiothoracic surgeon at Virginia Mason Clinic, Seattle; Dr. Cathy Greenberger, internist in Boston, Massachusetts; Dr. Jean Gispen, rheumatologist in Oxford, Mississippi; Dr. Douglas C. Guyton, anesthesiologist in Phoenix, Arizona; Dr. James L. Guyton, orthopedic surgeon at Campbell's Clinic in Memphis, Tennessee; Dr. Thomas S. Guyton, Assistant Professor of Anesthesiology, University of Florida School of Medicine, Gainesville; and Dr. Gregory P. Guyton, resident in orthopedics at University of Iowa School of Medicine.
Over the past six decades, medical science has recognized the contributions of Arthur C. Guyton. Today, we mourn his passing but salute his many accomplishments. He is a Mississippi success story: born and educated in Mississippi, he returned to the Magnolia State to teach and research. The impact of Dr. Guyton's work on the present and future of Mississippi's health care community is immeasurable. Arthur Guyton was a blessing to Mississippi. He will be missed; but he will be remembered.